Özlem Taştan Bishop

This study identifies the N-terminal region of 1-giardin as essential for oligomerization and lipid-binding, revealing its role in UPS and parasite virulence.

This study identifies and validates FDA-approved drugs as inhibitors of CLIC4 using structural bioinformatics and experimental assays.

The paper analyzes mutations in Omicron sub-lineages to understand their impact on S protein-hACE2 interactions and allosteric communications, finding increased transmissibility through conformational changes.

The paper derives AMBER force field parameters for Fe2+4S2-4 clusters in DPD enzyme to improve in silico studies of 5-FU drug metabolism and toxicity.

MDM-TASK-web provides a web server for MD-TASK and MODE-TASK software to analyze protein dynamics with visualization tools and updated functionalities.

The paper investigates how emerging mutations affect the dynamic properties of SARS-CoV-2 main protease using molecular dynamics simulations and identifies potential allosteric targets.

The paper identifies sequence and structural differences between falcipains and human cathepsins to design selective peptide inhibitors for malaria treatment.

The paper identifies three natural compound allosteric modulators of Hsp90 and assesses their effect on the protein's conformational dynamics.

This study identifies differences between plasmodium and human aminoacyl tRNA synthetases through bioinformatics analysis, revealing potential druggable sites for antimalarial drugs.

This paper characterizes drug resistance in HIV protease by analyzing structural dynamics, finding conserved regions of expansion and compaction linked to resistance across eight protease inhibitors.

MODE-TASK provides tools for analyzing protein motion using molecular dynamics and normal mode analysis techniques.

The paper investigates associations between APOL1 variants and HAT risk in Ugandan populations, finding no significant associations after correction for multiple testing.

This study uses computational methods to analyze how ATP and ADP affect the conformational dynamics of human Hsp90, identifying key residues involved in allosteric modulation.