The SMAC Mimetic AZD5582 is a Potent HIV Latency Reversing Agent
Gavin C. Sampey, David M. Irlbeck, Edward P. Browne, Matthew Kanke, Alecia B. McAllister, Robert G. Ferris, Jessica H. Brehm, David Favre, Jean-Pierre Routy, Corbin D. Jones, Nancie M. Archin, David M. Margolis, Richard M. Dunham
The paper demonstrates that AZD5582, a SMACm mimic, effectively reverses HIV latency in patient-derived cells without significant off-target effects.
bioRxiv · May 2, 2018 · PreprintMicrobiology