Attenuation of IFITM proteins antiviral activity through sequestration into intraluminal vesicles of late endosomes
David Přikryl, You Zhang, Smita Verma, Gregory B. Melikyan
This study shows that CsA treatment sequesters IFITM proteins into intraluminal vesicles of late endosomes, reducing their antiviral activity by preventing viral fusion with the limiting membrane of these compartments.
Frontiers in Immunology · Aug 21, 2025Peer-reviewedMicrobiology