A Sequential Binding Mechanism for 5' Splice Site Recognition and Modulation for the Human U1 snRNP
David S. White, Bryan M. Dunyak, Frédéric H. Vaillancourt, Aaron A. Hoskins
This study identifies a sequential binding mechanism by which branaplam modulates U1 snRNP recognition of -1A bulged 5' splice sites.
bioRxiv · Apr 18, 2024Biochemistry