Aaron A. Hoskins

This study investigates the role of Cwc15p in S. cerevisiae splicing, finding it stabilizes and facilitates structural transitions of the spliceosome active site, important for splicing under nonoptimal conditions.

The paper shows that U1-70K promotes exon definition by destabilizing U1-5' SS interactions, leading to exon skipping when depleted.

This study shows TDP-43 binds to GU repeats with high affinity, prevents pUG fold formation, and reveals an interplay between RNA folding and protein recognition.

This paper develops a yeast-based high-throughput screening platform to identify small molecules modulating pre-mRNA splicing, identifying 4 compounds and showing one affects splicing in cancer cells with a splicing factor mutation.

This study shows that a specific amino acid in the Prp8 protein influences 3' splice site selection in yeast by interacting with the -3 pyrimidine of the 3SS, affecting splicing efficiency and 3SS competition.

The paper identifies variants in PRPF8 and related genes associated with CAKUT, showing their role in splicing and ciliogenesis through functional experiments.

This study shows that pladienolide B inhibits Cryptococcus neoformans growth and spore germination, with enhanced efficacy when combined with FK506 or clorgyline.

This study uses CoSMoS to analyze how RNA modifications and Prp24 influence Lsm2-8 binding dynamics during U6 snRNP assembly in yeast.

This study uses CoSMoS to show that Prp38, Snu23, and Spp381 form a BCP subcomplex that binds to pre-mRNA after tri-snRNP and releases after NTC association, with conserved dynamics in yeast and humans.

This study identifies a sequential binding mechanism by which branaplam modulates U1 snRNP recognition of -1A bulged 5' splice sites.

This study investigates how the yeast splicing factor Fyv6 influences 3' splice site selection through transcriptomic, structural, and genetic analyses.

This study investigates the role of zinc finger domains in the yeast splicing factor Luc7 using humanized variants, revealing their impact on splice site selection and interactions with Prp28.

The paper shows that U6 snRNA made by RNA polymerase II is less stable but still functional in yeast, and that Sm protein binding can enhance its stability.