Adventitial leptin receptor-expressing fibroblasts are preferential contributors to fibrotic remodeling of the heart post infarction
Veronica Larcher, Ariane Fischer, Lunfeng Zhang, Omar Almolla, Mattia Chiesa, Francesca Andriani, Chiara Wernet, Simone Serio, Lukas Stefan Tombor, Sofia Peruzzo, Debanjan Mukherjee, Rossana Bussani, Serena Zacchigna, Ralf H. Adams, Stefanie Dimmeler, , Nuno Guimarães‐Camboa
This study identifies adventitial leptin receptor-expressing fibroblasts as key contributors to cardiac fibrosis after myocardial infarction in mice and humans.
bioRxiv · Oct 14, 2025 · PreprintCell Biology