PFAS triggers a SpoT-associated metabolic switch that promotes persister-like phenotype in Salmonella Typhi
Debayan Ganguli, Shramana Chakraborty, Shreya Dasgupta, Sameer Ranjan Sahoo, Debjani Bhattacharya, Sudip Dey, Ananda Pal, Ratan Gachhui, Santasabuj Das
This study shows PFAS exposure causes membrane depolarization in Salmonella Typhi, leading to metabolic reconfiguration and increased persister-like cells through SpoT-dependent stringent response activation.
bioRxiv · May 12, 2026 · PreprintMicrobiology