Impaired synaptic inhibition and enhanced aversion encoding by lateral habenula neurons during Δ9-tetrahydrocannabinol withdrawal.
Eun-Kyung Hwang, Deborah Daphne, C. Maddox, Agustín G. Zapata, Alexander F. Hoffman, Carl R. Lupica
This study shows that Δ9-THC withdrawal increases LHb responsivity to aversive stimuli through impaired synaptic inhibition and altered E-I balance.
bioRxiv · Nov 24, 2025 · PreprintNeuroscience