Impaired synaptic inhibition and enhanced aversion encoding by lateral habenula neurons during Δ9-tetrahydrocannabinol withdrawal.
Eun-Kyung Hwang, Deborah Daphne, C. Maddox…·Carl R. Lupica
This study shows that Δ9-THC withdrawal increases LHb responsivity to aversive stimuli through impaired synaptic inhibition and altered E-I balance.