Genome-Wide Variations of End Motif in Cell-Free DNA Fragments Distinguish Immunotherapy Responders from Non-Responders in Head and Neck Cancer: A Multi-Institute Prospective Study
Ravi Bandaru, Hailu Fu, Haizi Zheng, Jocelyn Liang, Li Wang, Shuchi Gulati, Benjamin H. Hinrichs, Mingxiang Teng, Bin Zhang, Marsha Kocherginsky, Dechen Lin, David A. Hildeman, Francis Paul Worden, Matthew Owen Old, Neal Dunlap, , Yaping Liu
This study identifies a novel cfDNA fragmentomic metric, rMDS, that distinguishes immunotherapy responders from non-responders in HNSCC with high accuracy.
medRxiv · Mar 30, 2026 · PreprintGenetic & Genomic Medicine