Hailu Fu

This study identifies a novel cfDNA fragmentomic metric, rMDS, that distinguishes immunotherapy responders from non-responders in HNSCC with high accuracy.

The paper identifies an NTRK2 isoform switch in BPD lungs that impairs endothelial regeneration and shows that restoring full-length NTRK2 mRNA can reverse alveolar damage.

This study identifies circulating cell-free DNA methylation profiles as potential non-invasive biomarkers for multiple sclerosis, showing their ability to classify subtypes, estimate severity, and predict progression.

FinaleMe predicts DNA methylation and tissues-of-origin from plasma whole-genome sequencing by using a non-homogeneous Hidden Markov Model.

NOMe-HiC jointly profiles genetic variants, DNA methylation, chromatin accessibility, and 3D genome structure from the same DNA molecule, showing high concordance with mono-omic assays and revealing coordinated chromatin accessibility in spatially proximal regions.

The paper develops a method to identify cell-free DNA fragmentation hotspots in plasma whole-genome sequencing and shows their utility in detecting early-stage cancers with high specificity and sensitivity.