Li Wang

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

This study identifies a novel cfDNA fragmentomic metric, rMDS, that distinguishes immunotherapy responders from non-responders in HNSCC with high accuracy.

This study identifies circulating cell-free DNA methylation profiles as potential non-invasive biomarkers for multiple sclerosis, showing their ability to classify subtypes, estimate severity, and predict progression.

NOMe-HiC jointly profiles genetic variants, DNA methylation, chromatin accessibility, and 3D genome structure from the same DNA molecule, showing high concordance with mono-omic assays and revealing coordinated chromatin accessibility in spatially proximal regions.

The paper introduces HiDRA, a method for high-resolution functional analysis of regulatory regions, identifying 13,000 driver elements and linking them to disease-associated variants.