Lepr Haploinsufficiency Accelerates Alzheimer-like Neurodegeneration via CDK5 Hyperactivation
Sangita Chowdhury Paul, Juhi Bhardwaj, Srishti Sharma, Mohammed Swalih, Deepanshi Koul, Balachandran Krishnamma Binukumar
This study shows that Lepr haploinsufficiency accelerates Alzheimer-like neurodegeneration in mice through CDK5 hyperactivation and identifies pathogenic LEPR variants in humans.
bioRxiv · Aug 28, 2025 · PreprintNeuroscience