NeurosciencebioRxivPreprint
Lepr Haploinsufficiency Accelerates Alzheimer-like Neurodegeneration via CDK5 Hyperactivation
Sangita Chowdhury Paul, Juhi Bhardwaj, Srishti Sharma…·Balachandran Krishnamma Binukumar
This study shows that Lepr haploinsufficiency accelerates Alzheimer-like neurodegeneration in mice through CDK5 hyperactivation and identifies pathogenic LEPR variants in humans.
DOI 10.1101/2025.08.28.672812