Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3
Jarrett Smith, Deepika Calidas, Helen Schmidt, Tu Lu, Dominique Rasoloson, Geraldine Seydoux
The paper shows that MEG-3, an intrinsically disordered protein, forms P granules in C. elegans zygotes through RNA-induced phase separation, and that MEX-5 suppresses this process in the anterior cytoplasm.
eLife · Dec 3, 2016Peer-reviewedMolecular Biology