Targeted mutagenesis in Ehrlichia canis deleting the phage head-to-tail connector protein gene and its assessment as a vaccine candidate preventing canine ehrlichiosis
Dominica D. Ferm, Arathy D. S. Nair, Jonathan D. Ferm, Huitao Liu, Ying Wang, Liliana F. Crosby, Jodi F. McGill, Perle Latré de Laté, Ian Matthew Stoll, Deepika Chauhan, Debika Choudhury, Swetha Madesh, Suhasini Ganta, Alexandra Burne, Sezayi Özübek, , Roman R. Ganta
This study deletes the phtcp gene in E. canis using targeted mutagenesis and shows the mutant induces immunity against wild-type infection in dogs.
Vaccine · Mar 16, 2026Peer-reviewedMicrobiology