The folding, dimerization and allosteric landscapes of the ALS protein SOD1: a comprehensive mutational atlas
Tomas Quiroga, Laz Ashcroft, Lauren J. Rice, Defne Boratav, Mariano Martín, Juan Francisco Vazquez-Costa, Bryony A. Thompson, Luke McAlary, Benedetta Bolognesi
This study maps the mutational landscape of SOD1 by analyzing monomer folding and dimerization, identifying protein destabilization as a key driver of ALS and uncovering potential therapeutic targets.
bioRxiv · Jul 16, 2026 · PreprintBiophysics