Lauren J. Rice

This study uses single-molecule techniques to show how Hsp90 helps Hsp70 release folding intermediates and remodel client proteins to enable proper refolding.

This study maps the mutational landscape of SOD1 by analyzing monomer folding and dimerization, identifying protein destabilization as a key driver of ALS and uncovering potential therapeutic targets.

This paper shows that HspB1 and HspB5 differentially regulate TDP-43LCD condensation and aggregation, with HspB1 increasing dynamic exchange and HspB5 delaying pathological transition.

This study uses single-molecule techniques to characterize how human sHsps bind to aggregation-prone client proteins and form complexes.