Author

Juan Francisco Vazquez-Costa

Hospital Universitari i Politècnic La FeORCID 0000-0002-3043-7938Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Ana Rodríguez-RomanoiD· 1 shared Benedetta BolognesiiD· 1 shared Bryony A. ThompsoniD· 1 shared Defne Boratav· 1 shared Juan Gonzalez-ValdiviesoiD· 1 shared Laura Moreno‐MartíneziD· 1 shared Lauren J. RiceiD· 1 shared Laz AshcroftiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Ana Rodríguez-RomanoORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJul 16, 2026

The folding, dimerization and allosteric landscapes of the ALS protein SOD1: a comprehensive mutational atlas

Tomas Quiroga, Laz Ashcroft, Lauren J. Rice…·Benedetta Bolognesi

This study maps the mutational landscape of SOD1 by analyzing monomer folding and dimerization, identifying protein destabilization as a key driver of ALS and uncovering potential therapeutic targets.

DOI 10.64898/2026.07.15.738613

humanproteomics

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NeurosciencebioRxivPreprintNov 14, 2023

Injectable borax-loaded alginate hydrogels reduce muscle atrophy, modulate inflammation, and generate neuroprotection in the SOD1G93A mouse model of ALS via activation of the IGF-Akt-mTOR axis pathway.

Ana Rodríguez-Romano, Juan Gonzalez-Valdivieso, Laura Moreno‐Martínez…·Patricia Rico

The paper demonstrates that injectable borax-loaded alginate hydrogels improve motor function and survival in SOD1G93A mice by activating the IGF-Akt-mTOR pathway in muscle, reducing atrophy and inflammation.

2 citations

mouseexperimental assay

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