Claudin-dependent clonal expansion couples epicardial activation to regenerative fate acquisition
Sofia Kagioglou, Inika Prasad, Tuba Majid, Christopher Yu Tai Yen, Sabrina F. Syamsul, Lea M. Vettermann, Delfina Perez, Alberto S. Ceccarelli, Linda Renata Micali, Zeyu Yao, Osvaldo Chara, Elif Eroğlu
This study shows that clonal expansion driven by Claudins is necessary for epicardial cells to transition into regenerative EPDCs after injury.
bioRxiv · Oct 2, 2026 · PreprintCell Biology