Osvaldo Chara

This study shows that clonal expansion driven by Claudins is necessary for epicardial cells to transition into regenerative EPDCs after injury.

StressNET infers intercellular mechanical stresses from tissue geometry using a Graph Neural Network, achieving state-of-the-art performance in zebrafish and Xenopus embryos.

The paper identifies two thresholds of Brachyury expression in NMPs that determine lineage potential and axis-forming ability in vitro.

The paper models how progenitor addition and vacuolation interact in zebrafish notochord development, showing a feedback mechanism that maintains tissue proportions during elongation.

This study uses a computational model to show that local cell proliferation control through a delayed switch enables neuromast regeneration in zebrafish.

This study shows ethylene regulates root radial expansion by modulating cell wall mechanics through Auxin Response Factor1 and CESA gene repression in response to soil compaction.

ForSys estimates intercellular stresses and intracellular pressures from time-lapse microscopy, validated in silico and in vivo using Xenopus embryos and zebrafish.

This study shows that mechanical properties and YAP/TAZ activity influence position-dependent cell proliferation during axolotl limb regeneration.

The paper investigates how Shh+ floor plate cells contribute to spinal cord regeneration in axolotls by tracking their fate and analyzing gene expression dynamics.

This study develops a computational model to show that a reaction-diffusion mechanism can explain spinal cord regeneration in axolotls by controlling cell response and signal propagation.

The paper shows that asymmetrical ROS metabolism in Hydra leads to distinct injury-induced ROS signaling in apical and basal regenerating tips, driving different regenerative responses.

The paper identifies Tig1 as a regulator of proximo-distal identity during salamander limb regeneration through single-cell RNAseq analysis.

This study analyzes how tissue size affects morphogen distribution in reaction-diffusion models, identifying a crossover size where finite and infinite domain models behave differently.

The paper uses modeling and experimental data to show that a signal recruits ependymal cells within a specific spatiotemporal window during axolotl spinal cord regeneration.

This study examines the post-embryonic development and aging of the appendicular skeleton in axolotls, showing continuous ossification and cellular changes throughout life.

This study shows cell recruitment drives Vg pattern overscaling in Drosophila wing development, leading to wing size reduction when recruitment is impaired.

The paper identifies a conserved LPA signaling pathway that controls apical membrane size and maintains epithelial organization in neuroepithelial rosettes.

This study identifies a dynamic high-proliferation zone in axolotl regenerating spinal cord and shows accelerated cell divisions drive outgrowth.