Meningeal dendritic cells-astrocytes interactions elevate the kynurenine metabolic pathway to sustain neuropathic pain
Alexandre G.M. Maganin, Guilherme Rabelo de Souza, Miriam M. Fonseca, Alexandre H. Lopes, Rafaela Mano Guimarães, André Dagostin, Nerry T. Cecílio, Atlante S. Mendes, William Antônio Gonçalves, Conceição Elidianne Aníbal Silva, Francisco Isaac Fernandes Gomes, Lucas Maciel Mauriz Marques, Rangel L. Silva, Letícia Arruda, Denis A. Santana, , Thiago M. Cunha
This study identifies the kynurenine metabolic pathway as a key factor in sustaining neuropathic pain through interactions between meningeal dendritic cells and astrocytes.
Journal of Clinical Investigation · Oct 13, 2022Peer-reviewedNeuroscience