IGF2 mediates Hippo signaling to control liver size
Zhenxing Zhong, Ruxin Jin, Ying Zhong, Li Zhang, Deqian Chen, Zhihan Jiao, Fanhui Zhou, Rui Zhu, Jian Wu, Rui Dong, Kuiran Dong, Fei Lan, Yu Wang, Kun‐Liang Guan, Fa‐Xing Yu
This study identifies IGF2 as a mediator of Hippo signaling in liver size control, showing its role in promoting liver growth and hepatoblastoma through IGF1R activation.
bioRxiv · Oct 27, 2024 · PreprintCell Biology