Impaired migration and premature differentiation underlie the neurological phenotype associated with PCDH12 loss of function
Jennifer Rakotomamonjy, Lauren E. Rylaarsdam, Lucas Fares‐Taie, Sean McDermott, Devin Davies, George Yang, Fikayo Fagbemi, Maya Epstein, Alicia Guemez‐Gamboa
This study shows that PCDH12 loss impairs cerebral organoid development and neuronal migration, leading to neurodevelopmental disorders.
bioRxiv · Jan 5, 2023 · PreprintNeuroscience