Lauren E. Rylaarsdam

This study maps early postnatal DNA methylation dynamics in the mouse brain, revealing subtype-specific methylation changes and their disruption in Rett syndrome.

This study examines how the PACS1 p.R203W variant affects the proteomic landscape of brain organoids, identifying dysregulated proteins and processes linked to neurodevelopmental disorders.

The paper introduces sciMETv3, a high-throughput single-cell DNA methylation profiling method, achieving 100-fold higher cell throughput and compatibility with multimodal assays.

This study uses iPSC-derived neurons to show that the PACS1 p.R203W variant causes synaptic signaling deficits and prolonged neuronal network bursts in human neurons.

sciMET-cap reduces sequencing burden for single-cell methylation analysis while enabling accurate cell type assignment and near-complete methylome reconstruction.

This study shows that PCDH12 loss impairs cerebral organoid development and neuronal migration, leading to neurodevelopmental disorders.