Frequent Whole-Genome Duplication Events Drive the Genomic Evolution of Triple-Negative Breast Cancer During Neoadjuvant Chemotherapy
Devin P Bendixsen, Fiona Semple, Alastair J. Ironside, Mustafa İsmail Özkaraca, Natalie Wilson, Alison M. Meynert, Ailith Ewing, Colin A M Semple, Olga Oikonomidou
This study tracks genomic changes in TNBC during neoadjuvant chemotherapy, finding that whole-genome duplication events drive structural alterations and contribute to tumor evolution and response to treatment.
bioRxiv · Nov 17, 2025 · PreprintGenomics