Author

Diane M. Demas

Georgetown University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ayesha N. Shajahan‐HaqiD· 2 shared William T. BaumanniD· 2 shared Pavel KraikivskiiD· 1 shared Wei HeiD· 1 shared Wei HeiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersSystems Biology

Ayesha N. Shajahan‐HaqORCID

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2 papers

Recent·Most cited

WEE1 inhibition delays resistance to CDK4/6 inhibitor and antiestrogen treatment in estrogen receptor-positive breast cancer

Wei He, Diane M. Demas, Pavel Kraikivski, Ayesha N. Shajahan‐Haq, William T. Baumann

This study shows that alternating WEE1 inhibition with CDK4/6 inhibitor and antiestrogen treatment delays resistance in ER+ breast cancer cells.

npj Systems Biology and Applications · Nov 17, 2025Peer-reviewedSystems Biology

Modeling Breast Cancer Proliferation, Drug Synergies, and Alternating Therapies

Wei He, Diane M. Demas, Ayesha N. Shajahan‐Haq, William T. Baumann

This study develops a mathematical model to simulate drug responses in ER+ breast cancer, identifying synergistic combinations and optimizing alternating therapies to reduce resistance and drug dose.

iScience · Apr 23, 2023Peer-reviewedSystems Biology