Wei He

The paper develops a probability distribution for rare subclones in cancer and applies it to simulate dynamic precision medicine to improve treatment outcomes despite sequencing limitations.

This study enhances a personalized cancer treatment strategy by incorporating both irreversible and reversible drug resistance mechanisms, showing improved patient outcomes compared to current approaches.

This study develops a mathematical model to simulate drug responses in ER+ breast cancer, identifying synergistic combinations and optimizing alternating therapies to reduce resistance and drug dose.

This study shows DISC1-NTM mice have impaired risk avoidance, linked to reduced activity in nucleus accumbens parvalbumin interneurons.