Liebig's law of the minimum in the TGF-β/SMAD pathway
Yuchao Li, Difan Deng, Chris Tina Höfer, Jihye Kim, Won Do Heo, Quanbin Xu, Xuedong Liu, Zhike Zi
The paper shows that TGF-β signaling responses are determined by the receptor with the lowest abundance, following Liebig's law of the minimum, across cell types and single cells.
PLoS Computational Biology · May 16, 2024Peer-reviewedSystems Biology