Author

Quanbin Xu

University of Colorado BoulderORCID 0000-0002-2833-9773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Xuedong LiuiD· 2 shared Cathryn M Toomey· 1 shared Chris Tina HöferiD· 1 shared Difan Deng· 1 shared Dylan J. TaatjesiD· 1 shared Gilson J. SancheziD· 1 shared Graycen E. WheeleriD· 1 shared Jessica Westfall· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Xuedong LiuORCID

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2 papers

Recent·Most cited

Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4

Gilson J. Sanchez, Zeyu Liu, Samuel Hunter, Quanbin Xu, Jessica Westfall, Graycen E. Wheeler, Cathryn M Toomey, Dylan J. Taatjes, Mary Ann Allen, Robin D. Dowell, Xuedong Liu

This study shows largazole suppresses superenhancer accessibility by inhibiting SP1 and BRD4, leading to mitotic chromosome misalignment and cell cycle arrest.

bioRxiv · Jan 29, 2025 · PreprintCancer Biology

Liebig's law of the minimum in the TGF-β/SMAD pathway

Yuchao Li, Difan Deng, Chris Tina Höfer, Jihye Kim, Won Do Heo, Quanbin Xu, Xuedong Liu, Zhike Zi

The paper shows that TGF-β signaling responses are determined by the receptor with the lowest abundance, following Liebig's law of the minimum, across cell types and single cells.

PLoS Computational Biology · May 16, 2024Peer-reviewedSystems Biology