Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowth
Ruby Oberin, Sigrid Petautschnig, Ellen G. Jarred, Zhipeng Qu, Te‐Sha Tsai, Neil A. Youngson, Gabrielle Pulsoni, Thi T. Truong, Dilini Fernando, Heidi Bildsoe, Rheannon O Blücher, Maarten van den Buuse, David K. Gardner, Natalie A. Sims, David L. Adelson, Patrick S. Western
The paper shows that loss of EED in mouse oocytes initially restricts fetal growth but later leads to placental hyperplasia and offspring overgrowth.
eLife · May 7, 2024Peer-reviewedDevelopmental Biology