David L. Adelson

This study validates the multi-target, multi-pathway action of Compound Kushen Injection by knocking out key genes in cell lines and observing changes in CKI efficacy.

This study expands the known distribution of R2 retrotransposons across animal taxa, identifies new avian candidates, and reveals lineage-specific structural and functional diversity.

The paper presents telomere-to-telomere genome assemblies of a Thoroughbred horse and donkey derived from a mule, revealing insights into equid centromere evolution and plasticity.

The paper characterizes CR1-group retrotransposons across chordates, revealing new phylogenetic relationships, older origins, and novel elements, along with horizontal transfer events.

This study investigates the therapeutic effects of Compound Kushen Powder and Injection on radiation-induced gastrointestinal mucositis in rats, identifying shared and distinct molecular mechanisms.

The paper reports cryo-EM structures of A-clade R2 retrotransposon proteins during key steps of transgene insertion and identifies features contributing to their selectivity and function.

This study identifies AMHY as the primary male sex determination gene in monotremes by analyzing its expression and function during sexual differentiation.

The paper shows that loss of EED in mouse oocytes initially restricts fetal growth but later leads to placental hyperplasia and offspring overgrowth.

The paper introduces a method to identify eQTLs and improve transcriptome analysis by quantifying differential allelic representation in RNA-sequencing data.

The paper identifies that GTF2IRD2 misannotates DNA transposons in non-mammalian species, leading to errors in phylogenetic analysis and gene regulation studies.

This paper assembles the genome of Sophora flavescens, revealing significant transposon and gene expansion, and characterizes gene expression and bioactive compound biosynthesis pathways.

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

The paper identifies a transient period of PRC2 activity in mouse and human oocytes that represses developmental genes, with conservation in human germline but loss during early embryonic development.

The paper identifies widespread horizontal gene transfer events in eukaryotic genomes across multiple species and shows their impact on genome evolution.

The paper describes horizontal transfer of the Harbinger-Snek DNA transposon into sea kraits and its rapid genomic expansion, contributing to adaptation to an amphibious-marine lifestyle.

This study uses a zebrafish model of familial Alzheimer’s disease to show accelerated brain aging and transcriptional inversion linked to glucocorticoid resistance and immune pathway changes before histopathology.

The paper presents the tuatara genome, highlighting its evolutionary significance and unique features compared to other vertebrates.

The paper introduces CARP, an ab initio pipeline for identifying and annotating TEs and segmental duplications in genome assemblies, showing it outperforms RepeatModeler.

The paper identifies widespread horizontal transfer of LINE-1 and BovB transposable elements between species using a 503-genome dataset, showing their impact on mammalian genome evolution.

The paper analyzes the genome-wide impact of transposable elements on gene regulation, finding that Alu elements are associated with upregulated gene expression and contribute more to regulatory regions than ancient TEs.

The paper identifies 31,566 novel protein-coding transcripts and estimates the total human protein-coding transcripts to be over 200,000 by integrating genomic, transcriptomic, and proteomic data.