Author

Patrick S. Western

Hudson Institute of Medical ResearchORCID 0000-0002-7587-8227Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Ellen G. JarrediD· 3 shared David K. GardneriD· 2 shared David L. AdelsoniD· 2 shared Heidi BildsoeiD· 2 shared Maarten van den BuuseiD· 2 shared Natalie A. SimsiD· 2 shared Rheannon O BlücheriD· 2 shared Ruby OberiniD· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Ellen G. JarredORCID

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3 papers

Recent·Most cited

Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowth

Ruby Oberin, Sigrid Petautschnig, Ellen G. Jarred, Zhipeng Qu, Te‐Sha Tsai, Neil A. Youngson, Gabrielle Pulsoni, Thi T. Truong, Dilini Fernando, Heidi Bildsoe, Rheannon O Blücher, Maarten van den Buuse, David K. Gardner, Natalie A. Sims, David L. Adelson, Patrick S. Western

The paper shows that loss of EED in mouse oocytes initially restricts fetal growth but later leads to placental hyperplasia and offspring overgrowth.

eLife · May 7, 2024Peer-reviewedDevelopmental Biology

FGF independent MEK1/2 signalling is essential for male fetal germline development in mice

Rheannon O Blücher, Rachel S. Lim, Ellen G. Jarred, Matthew E. Ritchie, Patrick S. Western

The paper shows that MEK1/2 signaling is essential for male fetal germline development in mice, while FGF signaling has a limited role.

bioRxiv · Feb 5, 2023 · PreprintDevelopmental Biology

Transient Polycomb activity represses developmental genes in growing oocytes.

Ellen G. Jarred, Zhipeng Qu, Te‐Sha Tsai, Ruby Oberin, Sigrid Petautschnig, Heidi Bildsoe, Stephen Pederson, Qing-Hua Zhang, Jessica M. Stringer, John Carroll, David K. Gardner, Maarten van den Buuse, Natalie A. Sims, William T. Gibson, David L. Adelson, Patrick S. Western

The paper identifies a transient period of PRC2 activity in mouse and human oocytes that represses developmental genes, with conservation in human germline but loss during early embryonic development.

Clinical Epigenetics · Dec 1, 2022Peer-reviewedDevelopmental Biology