Integrated single-nucleotide and structural variation signatures of DNA-repair deficient human cancers
Tyler Funnell, Allen Zhang, Yu-Jia Shiah, Diljot Grewal, Robert Lesurf, Steven McKinney, Ali Bashashati, Yi Kan Wang, Paul C. Boutros, Sohrab P. Shah
This study introduces a machine learning method to infer mutation signatures from both single nucleotide and structural variations in DNA repair deficient cancers, identifying new age-related and HRD-associated signatures in breast and ovarian cancers.
bioRxiv · Feb 18, 2018 · PreprintCancer Biology