α-Synuclein Activates the PI3K/AKT Pathway to Drive Lipid Droplets Accumulation: Implications for Parkinson's Disease
Suaad Abd Elhadi, Jenna Congdon-Loeffler, Eva Harrosch, Dima Khatib, Lama Naamneh, Meir Schechter, Alexandra Eliassaf, Ori Shalev, Ronit Sharon
This study shows that α-synuclein activates the PI3K/AKT pathway, leading to lipid droplet accumulation in Parkinson's disease, and suggests PI3K inhibition as a therapeutic strategy.
bioRxiv · Mar 27, 2025 · PreprintNeuroscience