Author

Alexandra Eliassaf

Hebrew University of Jerusalem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Ori ShaleviD· 2 shared Alexane Cannella Miliano· 1 shared Anna Morshina· 1 shared Aurélie ErnstiD· 1 shared Batsheva KeremiD· 1 shared Dima Khatib· 1 shared Eva Harrosch· 1 shared F Castellani Moses· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Ori ShalevORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov, Shira Milo, Jan Otoničar, Michelle Chan, Michal Harel, Frauke Devens, Tchelet Goldberg, Alexandra Eliassaf, Karen Grimes, Michal Irony‐Tur Sinai, Gianluca Sigismondo, Tamar Geiger, Jan O. Korbel, , Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

bioRxiv · Apr 17, 2025 · PreprintCancer Biology

α-Synuclein Activates the PI3K/AKT Pathway to Drive Lipid Droplets Accumulation: Implications for Parkinson's Disease

Suaad Abd Elhadi, Jenna Congdon-Loeffler, Eva Harrosch, Dima Khatib, Lama Naamneh, Meir Schechter, Alexandra Eliassaf, Ori Shalev, Ronit Sharon

This study shows that α-synuclein activates the PI3K/AKT pathway, leading to lipid droplet accumulation in Parkinson's disease, and suggests PI3K inhibition as a therapeutic strategy.

bioRxiv · Mar 27, 2025 · PreprintNeuroscience

Disease-associated programming of cell memory in glycogen storage disorder type 1a

Uri Sprecher, J D’Souza, Kumudesh Mishra, Noam Muchtar, Or Shalev, Alexandra Eliassaf, Anna Morshina, Alexane Cannella Miliano, Gilles Mithieux, Fabienne Rajas, S Avraham, F Castellani Moses, H Kauffman, Yehudit Bergman, Nissim Garti, , Miguel Weil

This paper shows that GSD1a patient fibroblasts retain a reversible disease phenotype in vitro, driven by epigenetic and transcriptional changes, and that a drug can reverse these effects.

bioRxiv · Feb 20, 2023 · PreprintCell Biology