A remarkable case of conserved domain swapping in the COMMD family of proteins
Ryan J. Hall, Meihan Liu, Manuela K. Hospenthal, Dion J Celligoi, Rajesh Ghai, Kai‐En Chen, Joanna Sacharz, David A. Stroud, J. Shaun Lott, Michael D. Healy, Brett M. Collins
The paper determines crystal structures of COMMD family HN domains, revealing a conserved domain swapping mechanism regulated by hinge-loop conformational changes and phosphorylation.
bioRxiv · Feb 4, 2026 · PreprintBiochemistry