Brett M. Collins

This study identifies Copine-6 as a protein that links calcium, phosphoinositide, and Rab11 signals to regulate glutamate receptor recycling in neurons.

This study identifies bacterial and archaeal ancestors of eukaryotic COMMD proteins through structural and phylogenetic analysis, showing their origin from a single bacterial gene.

The paper identifies neuronal and astrocytic membrane proteins dependent on Retromer for endosomal recycling, highlighting SNX27-Retromer's role in glutamate transporter trafficking.

The paper determines crystal structures of COMMD family HN domains, revealing a conserved domain swapping mechanism regulated by hinge-loop conformational changes and phosphorylation.

This study identifies Gyp6 as a GAP that regulates Ypt7 activity through Retromer to coordinate endosomal carrier formation in yeast.

This study identifies Nischarin S-glutathionylation as a redox-regulated mechanism controlling cell migration and invasion in breast cancer by modulating Rac1 and PAK1 interactions.

The paper develops a method to express and visualize eukaryotic proteins using cell-free systems and cryo-electron tomography, demonstrating its application to study ASC protein filaments and their interaction with ribosomes.

This study identifies the RAB32-LRMDA-Commander complex and shows its role in melanosome biogenesis and pigmentation, revealing the mechanism of oculocutaneous albinism type 7.

The paper identifies Retromer as a hub for RAB GTPase regulation through proximity proteomics and biochemical analysis.

The paper identifies a new VPS29 isoform, VPS29C, which exhibits auto-inhibition limiting its association with Retriever and Retromer accessory proteins, revealing new complexity in Retromer function.

This study identifies specific unsaturated lipids as critical for caveola formation and their disassembly under oxidative stress.

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

This paper identifies Copine-6 as a Ca2+ sensor that mediates activity-induced AMPA receptor exocytosis, distinct from Syt-1 and Syt-7.

This study investigates the function of the ALS risk variant GGNBP2 in Drosophila motor neurons, showing it regulates autophagy and synaptic development.

The paper identifies key residues in Munc18-1 domain 3a that regulate the interaction with VAMP2, controlling nanoscale reorganization necessary for vesicular priming and secretion.

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

This study identifies LRFN2 as a new SNX27-dependent cargo that regulates AMPA receptor trafficking and synaptic function, revealing an indirect mechanism for SNX27's role in neurological conditions.

This study identifies CaMKIIα-mediated phosphorylation of GluN2A at Ser-1459 as a mechanism regulating NMDAR trafficking and gating, with implications for epilepsy.