Ryanodine receptor 1 ( RYR1 ) patient-derived muscle cells recapitulate disease phenotypes in 2D and 3D culture models
Joshua S. Clayton, Jordan Crane, Jeremy D. D. Garcia, Divya Avnoor, Anna C. Johnstone, Ria Aggarwal, Changho Chun, Vanessa G. Crossman, Peter J. Houweling, Edoardo Malfatti, Norma Beatriz Romero, David L. Mack, Nigel G. Laing, Gianina Ravenscroft, Rhonda L. Taylor
This study uses patient-derived iPSCs to create 2D and 3D muscle models that replicate RYR1 myopathy phenotypes and test therapeutic efficacy.
bioRxiv · Jun 20, 2026 · PreprintCell Biology