Phenotype-Based Probabilistic Analysis of Heterogeneous Responses to Cancer Drugs and Their Combination Efficacy
Natacha Comandante-Lou, Mehwish Khaliq, Divya G. Venkat, Mohan Manikkam, Mohammad Fallahi‐Sichani
This paper introduces probabilistic phenotype metrics to assess drug efficacy and combination effectiveness by analyzing single-cell responses, showing they reduce bias and improve sensitivity to heterogeneity.
PLoS Computational Biology · Feb 21, 2020Peer-reviewedSystems Biology