Author

Mehwish Khaliq

University of MichiganORCID 0000-0001-8757-8013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

Mohammad Fallahi‐SichaniiD· 2 shared Mohan ManikkamiD· 2 shared Divya G. Venkat· 1 shared Elisabeth D. MartíneziD· 1 shared Natacha Comandante-LouiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersSystems Biology

Mohammad Fallahi‐SichaniORCID

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2 papers

Recent·Most cited

Systems BiologyNature CommunicationsPeer-reviewedMar 9, 2021

Epigenetic modulation reveals differentiation state specificity of oncogene addiction

Mehwish Khaliq, Mohan Manikkam, Elisabeth D. Martínez, Mohammad Fallahi‐Sichani

The paper identifies epigenetic inhibitors that target specific differentiation states in melanoma cells, improving MAPK inhibitor efficacy based on tumor cell differentiation and MAPK activity.

24 citations

humanbulk RNA-seq

𝕏 PostBluesky

Systems BiologyPLoS Computational BiologyPeer-reviewedFeb 21, 2020

Phenotype-Based Probabilistic Analysis of Heterogeneous Responses to Cancer Drugs and Their Combination Efficacy

Natacha Comandante-Lou, Mehwish Khaliq, Divya G. Venkat…·Mohammad Fallahi‐Sichani

This paper introduces probabilistic phenotype metrics to assess drug efficacy and combination effectiveness by analyzing single-cell responses, showing they reduce bias and improve sensitivity to heterogeneity.

16 citations

statistical modeldrug response / drug discovery

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