MHC-Fine: Fine-tuned AlphaFold for Precise MHC-Peptide Complex Prediction
Ernest Glukhov, Dmytro Kalitin, Darya Stepanenko, Y. Zhu, Thu Nguyen, George S. Jones, T. Patsahan, Carlos L. Simmerling, Julie C. Mitchell, Sándor Vajda, Ken A. Dill, Dzmitry Padhorny, Dima Kozakov
The paper fine-tunes AlphaFold using high-resolution MHC-peptide crystal structures to improve prediction accuracy for MHC-peptide complex structures, outperforming existing methods in RMSD and lDDT scores.
Biophysical Journal · May 15, 2024Peer-reviewedBioinformatics