Ken A. Dill

RNA and proteins joined up at the origins of Life: Persistence is the point

The paper proposes a model showing how nucleic acids and proteins could have cooperatively bootstrapped each other to achieve autocatalytic functionality at the origins of life.

Generation of Pathway Signatures by Combining Normal Modes with Weighted Ensemble Simulations

This study combines normal modes with weighted ensemble simulations to generate unbiased protein pathways efficiently.

Brain signaling becomes less integrated and more segregated with age

The paper defines brain integration and segregation using the Ising model to analyze functional MRI data, finding that these states become less balanced with age.

MHC-Fine: Fine-tuned AlphaFold for Precise MHC-Peptide Complex Prediction

The paper fine-tunes AlphaFold using high-resolution MHC-peptide crystal structures to improve prediction accuracy for MHC-peptide complex structures, outperforming existing methods in RMSD and lDDT scores.

Early Path Dominance as a Principle for Neurodevelopment

The paper uses percolation theory to analyze brain development, finding that early white matter tracts become longest and densest, maintaining a giant cluster across aging and disease.

Metabolism modulates network synchrony in the aging brain

This study shows that aging reduces brain network synchrony, modeled as a critical point in communication strength, and demonstrates that metabolic changes can drive these global shifts.