Co-dissemination of anti-phage defence systems and multidrug resistance is associated with the seventh-pandemic Vibrio cholerae defensome
M. Mozammel Hoque, Joyce To, Dominic Leo, Diane McDougald, Jyl S. Matson, Gustavo Espinoza-Vergara
This study analyzes 1,740 Vibrio cholerae genomes to show that anti-phage defence systems and multidrug resistance co-disseminate via mobile genetic elements, with non-O1 strains harboring more diverse defences and O1 strains showing stronger associations between defence systems and AMR.
bioRxiv · Jul 13, 2026 · PreprintMicrobiology