Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma
Maya Shumer-Elbaz, Nitay Ad‐El, Yulia Chulanova, Dor Brier, Meir Goldsmith, Mike Bismuth, Alina Brosque, Roni Gattegno, Divsha Sher, Anna Gutkin, Dana Bar-On, Dinorah Friedmann‐Morvinski, Dan Peer, Tali Ilovitsh
This paper demonstrates that low-frequency ultrasound can safely open the blood-brain barrier to deliver lipid nanoparticles (LNPs) containing RNA to glioblastoma tumors in mice.
Journal of Controlled Release · Jul 7, 2025Peer-reviewedBioengineering