AMPK Signalling Rewires WWP1 mediated RUNX1 Ubiquitination in CML Progression
Abhayananda Behera, Sri Charitha Gorantla, Elina Rani Maddimadugu, Nagaraj Velugonda, Dora Babu Patchva, Sadasivudu Gundeti, Rama Krishna Kancha, Aramati B. M. Reddy
This study identifies WWP1 as a regulator of RUNX1 ubiquitination in CML, showing that AMPK modulates WWP1 and RUNX1 phosphorylation to influence leukemic progression.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology