Discovery of Scrophularia nodosa harpagoside synthase, a novel BAHD cinnamoyltransferase, bridges a key gap in the iridoid biosynthetic pathway
Dorian Rossi, Sheng Wang, Aude Pouclet, Yunyun Liu, David Pflieger, Etienne Grienenberger, Claire Parage, Ludivine Malherbe, Abdelmalek Alioua, Sandrine Koechler, Emmanuel Gaquerel, Danièle Werck‐Reichhart, Nicolas Navrot
The paper identifies and characterizes harpagoside synthase, a BAHD cinnamoyltransferase, as the enzyme responsible for the final step in harpagoside biosynthesis in Scrophularia nodosa.
bioRxiv · Apr 13, 2026 · PreprintPlant Biology