Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase
Sara Nunes Violante, Aye Kyaw, Lana Kouatli, Kaushik Paladugu, Lauren Apostolakis, Macy Jenks, Amy Johnson, Ryan D. Sheldon, Douglas A. Whitten, Anthony L. Schilmiller, Pablo E. Visconti, Justin R. Cross, Lonny R. Levin, Jochen Buck, Melanie Balbach
This study identifies how sperm increase metabolic flux through aldolase to meet energy demands during capacitation, revealing conserved metabolic regulation mechanisms in mammalian cells.
Proceedings of the National Academy of Sciences · Sep 24, 2025Peer-reviewedBiochemistry