Justin R. Cross

This paper shows that disrupting riboflavin biosynthesis in Mycobacterium tuberculosis leads to metabolic changes and loss of infectivity in mice.

This study shows that MEK inhibition reduces mitochondrial dysfunction and terminal CD8+ T cell exhaustion by decreasing nutrient uptake and RNA polymerase II activity.

This study shows that higher dietary fiber intake improves survival and reduces GVHD in hematopoietic cell transplant patients, with microbiome-mediated effects.

The paper shows gut microbiota regulates the intestinal kynurenine pathway through vitamin E absorption, using mouse models and computational analysis of microbiota associations.

This study shows cancer cells use macropinocytosis to take up extracellular DNA, which is then degraded to supply nucleotides, and highlights SLC29A3 as a key mediator of this process.

This study identifies how sperm increase metabolic flux through aldolase to meet energy demands during capacitation, revealing conserved metabolic regulation mechanisms in mammalian cells.

The paper uses machine learning to identify valeric acid as a bacterial metabolite that inhibits Candida parapsilosis growth through intracellular acidification, reducing fungal colonization in mice.

This paper develops a genetically encoded bifunctional enzyme that reduces redox imbalance and lipotoxicity by enhancing Gro3P biosynthesis and glycerol shunt in mammalian cells.

This study shows that limited amino acid availability in tumors impairs CD8+ T-cell cytotoxic function by reducing protein synthesis, and demonstrates strategies to restore this function.

The paper identifies hexa-acylated lipopolysaccharides from the gut microbiome as a biomarker and enhancer of anti-PD-1 immunotherapy responses in melanoma patients.

The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.

The paper identifies carboxylic acid levels in human skin odor as a factor influencing differential mosquito attraction and shows that genetic mutations affecting carboxylic acid receptors impair attraction to human scent.

The paper shows that gut microbes influence sympathetic neurons through a metabolite-mediated gut-brain circuit, with butyrate suppressing sympathetic activity.