The structural basis of huntingtin (Htt) fibril polymorphism, revealed by cryo-EM of exon 1 Htt fibrils
Sergey Nazarov, Anass Chiki, Driss Boudeffa, Hilal Ahmed Lashuel
This study uses cryo-EM to reveal the structural polymorphism of huntingtin exon1 fibrils, showing unique beta-hairpin arrangements and flanking domain organization.
bioRxiv · Sep 23, 2021 · PreprintNeuroscience